用于骨髓恶性肿瘤诊断的突变钙网蛋白

Mutant calreticulin for the diagnosis of myeloid malignancies

Abstract

The present invention relates to a method for diagnosing myeloid malignancy comprising determining the presence of a mutant allele of the calreticulin gene. Also genomic sequences, cDNA sequences, mRNA sequences and protein sequences of the mutant calreticulin are subject of the present invention. Further, the invention relates to medical uses of inhibitors of mutant calreticulin.
本发明涉及一种用于诊断骨髓恶性肿瘤的方法,该方法包含确定钙网蛋白基因的突变等位基因的存在。另外,所述突变钙网蛋白的基因组序列、cDNA序列、mRNA序列和蛋白质序列也是本发明的主题。再者,本发明涉及突变钙网蛋白的抑制剂的医疗用途。

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