A venlafaxine hydrochloride pharmaceutical composition and biological medicine uses thereof are disclosed. The composition comprises venlafaxine hydrochloride and a natural product compound (I) having a novel structure and separated from dry roots of licorice. When being used separately, the venlafaxine hydrochloride and the compound (I) both have a function of promoting fracture healing. When the venlafaxine hydrochloride and the compound (I) are used together, the function of promoting fracture healing is more obvious, and the venlafaxine hydrochloride and the compound (I) are synergistic. The composition can be developed into a medicine promoting facture healing. Compared with the prior art, the composition and the uses have significant substantive distinguishing features and significant improvements.